Can Probiotics Help Lower Your Cholesterol?

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Probiotics have been big news in the supplement space over the past few years. While these beneficial bacteria are most commonly used to treat a host of digestive disorders, they have also been positively associated with everything from allergies and liver disease to yeast infections, and even cancer.

There have even been several lab and animal studies showing that probiotics can help lower cholesterol. However, when it comes to probiotics and cholesterol levels in humans, the research is less conclusive. 

Given this, researchers from the University of Tabriz set out to test the effectiveness of probiotics in lowering cholesterol levels in men and women.[R]

Power Packed Yogurt

Researchers set up a double-blind, randomized study with 60 participants. All were between the ages of 30 and 60, had a BMI of less than 35 (35 or greater is considered morbidly obese), and had been diagnosed with type-2 diabetes for at least one year.

They also had LDL cholesterol levels of 2.6 mmol/L (or 100 mg/dL) or greater. LDL levels of less than 2.6 mmol/L are considered optimal, and 2.6 mmol/L to 3.3 mmol/L indicates a slightly increased risk for cardiovascular disease.

Researchers randomly divided the participants into two groups. The first group ate 300 grams of conventional yogurt a day for six weeks. This is the equivalent of 10.5 ounces.

 (The average container of yogurt is 6 ounces.) This yogurt contained naturally occurring probiotics (Lactobacillus bulgaricus and Streptococcus thermophilus).

The second group also ate 300 grams of the same yogurt daily for six weeks, but in addition to the naturally occurring probiotics, their yogurt had been fortified with additional Lactobacillus acidophilus and Bifidobacterium lactis. 

Both groups were instructed to maintain their other dietary habits and lifestyle. They were also told to avoid other yogurt and products containing probiotics.

At the beginning and end of the study, researchers took fasting blood samples of all participants, measuring their total cholesterol, triglyceride, HDL (good) and LDL (bad) levels, as well as the ratios between total cholesterol and HDL, and the ratios between LDL and HDL cholesterol.

Good Bugs, Good Health

At the end of the study period, researchers found that, first and foremost, there was excellent compliance, meaning that the participants happily ate the yogurt every day for the six weeks. Additionally, there were no adverse effects or symptoms associated with the yogurt.

On the cholesterol front, there was a significant difference between the two groups. Those in the fortified yogurt group had a 4.5 percent decrease in total cholesterol and a 7.5 percent decrease in LDL cholesterol, as compared to those in the regular group.

While triglycerides and HDL levels did not change in the fortified group, HDL levels did significantly decrease in the control group. (The study authors did not comment on what may be the reason behind the decrease in good cholesterol levels in the non-fortified group.)

Additionally, the fortified group saw a 5.4 percent reduction in their total cholesterol/HDL ratio, as well as an 8.6 percent decrease in their LDL/HDL ratio.

This is great news, as your cholesterol ratio can be a powerful indicator of cardiovascular risk. 

As a rule, your ratio is determined by dividing your total cholesterol by your HDL. So, if your total cholesterol is 160 and your HDL is 40, your ratio would be 4:1.

The American Heart Association suggests that you keep your ratio at or below 5:1, but notes that 3.5:1 is ideal. Therefore, the smaller the gap in the ratio, the better. This means that any decrease or reduction in your cholesterol ratio benefits your cardiovascular health.

Researchers concluded, “This trial showed that consumption of probiotic yogurt containing L. acidophilus La5 and B. lactis Bb12 could decrease serum [total cholesterol] and LDL [cholesterol] concentrations in type 2 diabetic people.”

They go on to suggest that probiotics-rich yogurt may help decrease cardiovascular disease risk factors in people with type-2 diabetes.

An Interesting Note

One very interesting note from the study was that previous research has indicated that probiotics supplements were not effective in lowering cholesterol.[R]

For some reason, the dairy found in the yogurt seemed to be a more effective way of delivering the probiotics’ benefits.

One possible reason for this may be that freeze-drying probiotics in order to encapsulate them may delay their ability to become metabolically active in the intestine.[R]

Got Yogurt?

The news just keeps getting better and better when it comes to probiotics, and yogurt specifically. Your best bet is to aim for one to two servings of yogurt daily. But be cautious in your selection.

When buying dairy-based yogurt, try to choose organic and plain/unsweetened. If you need a flavor boost, try liquid stevia (a calorie-free sweetener). There are even delicious flavored liquid stevias, including vanilla, English toffee and chocolate raspberry. That way you get the benefits of the yogurt without the sugar hit.

And if lactose is a concern, try a coconut milk based yogurt. It is a delicious and heart-healthy alternative to dairy!

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Scientific References

1. Dai YL, Luk TH, Yiu KH, et al. Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis. 2011 Jun;216(2):395-401.

2. Mehrabani, S., Askari, G., Miraghajani, M., Tavakoly, R., & Arab, A. (2019). Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies. Complementary Therapies in Medicine, 43, 181–187. doi: 10.1016/j.ctim.2019.01.022

3. Dumont, M., Kipiani, K., Yu, F., Wille, E., Katz, M., Calingasan, N. Y., … Beal, M. F. (2011). Coenzyme Q10 Decreases Amyloid Pathology and Improves Behavior in a Transgenic Mouse Model of Alzheimers Disease. Journal of Alzheimers Disease, 27(1), 211–223. doi: 10.3233/jad-2011-110209

4. Mezawa M, Takemoto M, Onishi S, et al. The reduced form of coenzyme Q10 improves glycemic control in patients with type 2 diabetes: An open label pilot study. Biofactors. 2012 Aug 8.

5. Hernández-Camacho, J. D., Bernier, M., López-Lluch, G., & Navas, P. (2018). Coenzyme Q10 Supplementation in Aging and Disease. Frontiers in Physiology, 9. doi: 10.3389/fphys.2018.00044

6. Crowley D.C., et al. “Bioavailability and Health Effects of CoQ10 in Healthy Human Adults.” May 11, 2006.

7. Kalén, A., Appelkvist, E.-L., & Dallner, G. (1989). Age-related changes in the lipid compositions of rat and human tissues. Lipids, 24(7), 579–584. doi: 10.1007/bf02535072

8. Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy. (2011). Iranian Journal of Kidney Diseases. doi: 21368390

9. Vargiu, R., Littarru, G. P., Faa, G., & Mancinelli, R. (2008). Positive inotropic effect of coenzyme Q10, omega-3 fatty acids and propionyl-L-carnitine on papillary muscle force-frequency responses of BIO TO-2 cardiomyopathic Syrian hamsters. BioFactors, 32(1-4), 135–144. doi: 10.1002/biof.5520320116

10. Johansson, P., Dahlström, Ö., Dahlström, U., & Alehagen, U. (2015). Improved health-related quality of life, and more days out of hospital with supplementation with selenium and coenzyme Q10 combined. Results from a double blind, placebo-controlled prospective study. The Journal of Nutrition, Health & Aging, 19(9), 870–877. doi: 10.1007/s12603-015-0509-9

11. Adarsh, K., Kaur, H., & Mohan, V. (2008). Coenzyme Q10(CoQ10) in isolated diastolic heart failure in hypertrophic cardiomyopathy (HCM). BioFactors, 32(1-4), 145–149. doi: 10.1002/biof.5520320117

12. Burke, B. E., Neuenschwander, R., & Olson, R. D. (2001). Randomized, Double-Blind, Placebo- Controlled Trial of Coenzyme Q10 in Isolated Systolic Hypertension. Southern Medical Journal, 94(11), 1112–1117. doi: 10.1097/00007611-200111000-00015

13. Zhai, J., Bo, Y., Lu, Y., Liu, C., & Zhang, L. (2017). Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis. Plos One12(1). doi: 10.1371/journal.pone.0170172

14. Lewin, A., & Lavon, H. (1997). The effect of coenzyme Q10 on sperm motility and function. Molecular Aspects of Medicine, 18, 213–219. doi: 10.1016/s0098-2997(97)00036-8

15. Preethi Srikanthan, Arun S. Karlamangla. Muscle Mass Index as a Predictor of Longevity in Older-Adults. The American Journal of Medicine, 2014; DOI: 10.1016/j.amjmed.2014.02.007

16. Folkers, K., & Simonsen, R. (1995). Two successful double-blind trials with coenzyme Q10 (vitamin Q10) on muscular dystrophies and neurogenic atrophies. Biochimica Et Biophysica Acta (BBA) – Molecular Basis of Disease, 1271(1), 281–286. doi: 10.1016/0925-4439(95)00040-b

17. Farsi, F., Mohammadshahi, M., Alavinejad, P., Rezazadeh, A., Zarei, M., & Engali, K. A. (2015). Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Journal of the American College of Nutrition, 35(4), 346–353. doi: 10.1080/07315724.2015.1021057